Biochemical and Morphofunctional Aspects of Aronia Melanocarpa Extract Intervention in Experimental Arterial Hypertension

Various epidemiological studies have shown an inverse association between the consumption of polyphenols or polyphenol-rich foods and the risk of cardiovascular diseases. The purpose of the study was to emphasize the effects of the polyphenolic extract from the isolated and purified vegetable material represented by the mature fruit of the Aronia melanocarpa on biochemical parameters and histopatological modifications. The experiment was performed on the arterial hypertension model. The significant lipid peroxide diminution in the serum contained by the HTA+P group compared to the P group is a result of a considerable reduction in the MDA serum concentration. The antioxidant capacity of the serum is significantly improved (p<0.001) in the HTA+P rats, as well as the GSH concentration being normalized. In the arterial hypertensive model the cardio-protective effects of the polyphenolic extract from Aronia melanocarpa are represented by the antioxidant, hypocolesterolemiant intervention. The extract also ensures the integrity of the vascular endothelium. Any clinical applications using polyphenolic extract should rely on an acurate understanding of the action mechanisms that are relevant.